Marine compounds open new therapeutic avenues for osteoarthritis

Persona de contacto: 
Dina Simes
Organismo: 
Universidade do Algarve-CCMAR
Dirección: 
Universidade do Algarve, campus de Gambelas
Código Postal: 
8005-139
Localidad: 
Faro
Provincia (NUT III): 
Algarve
Región (NUT II): 
Algarve
País: 
Portugal
Palabras clave: 
marine bioresources human health, pharmacological or advanced medical therapies
Calendario (indicativo): 
closes at 18th December
Origen geográfico de los socios que busca: 
Portugal: Alto Minho, Cávado, Ave, Área Metropolitana do Porto; Alto Tâmega, Tâmega e Sousa, Douro, Terra de Trás-os- Montes, beiras e Serra da Estrela, Beira Baixa Viseu Dão-Lafões, Região de Aveiro, Região de Coimbra, Médio Tejo, Região de Leiria, Oeste, Alto Alentejo, Alentejo Central, Baixo Alentejo, Alentejo Litoral, Algarve. Espanha: A Coruña, Lugo, Ourense, Pontevedra, León, Salamanca, Zamora, Valladolid, Ávila, Cáceres, Badajoz, Huelva, Cádiz, Córdoba, Sevilha.
Perfil de los socios que busca: 
Blue bioresources and biotechnology; Marine biotecnology; Marine Natural Products Chemistry; biofermentation; Microalgae and microbiology; Bioassay screening of secondary metabolites;
Descripción del proyecto: 
We propose to investigate the therapeutic potential of novel bioactive natural marine compounds, as novel Disease Modifying Drugs (DMDs) in the treatment of OA, with potential direct translational application. The protective effect of marine bioactive compounds will be explored in terms of disease modifying responses using a human in vitro OA model mimicking OA conditions, as a first approach to high throughput screening, followed by pre-clinical testing in vivo in OA mouse model for validation.

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