breast cancer, luminal A, luminal B, HER2-positive, and triple negative
Descrição do projeto:
Breast cancer (BC) is the most commonly diagnosed cancer in women worldwide. Today, even though major breast cancer subtypes have been characterized, i.e., luminal A, luminal B, HER2-positive, and triple negative, little is known about the heterogeneity of breast cancer in blood. In particular, phosphoproteins secreted or shed by cancer cells constitute a largely overlooked source of biomarker candidates that could be correlated with breast cancer subtypes and/or disease status.
The main objective of this proposal is discovering minimally invasive protein biomarkers in blood for the early noninvasive diagnosis, classification and monitorization of different breast cancer subtypes. These new blood-based biomarkers that are highly specific could offer the potential to decrease BC morbidity as well as identify the most appropriate treatment options.